5/25/2025
Last update
5/25/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 11 Reviews
8
Supplement Facts
Serving Size: 2 level tbsp (9 g)
Amount Per Serving
%DV
Calories
35
Total Fat
<0.5 g
<1%
Saturated Fat
0 g
0%
Trans Fat
0 g
Cholesterol
0 mg
0%
Sodium
0 mg
0%
Total Carbohydrate
3 g
1%
Dietary Fiber
2 g
7%
Total Sugars
0 g
Includes 0 g Added Sugars
0%
Protein
5 g
10%
Vit. D
0 mcg
0%
Iron
0.5 mg
2%
Thiamin
6 mg
500%
Niacin
32 mg
200%
Folate
675 mcg DFE (405 mcg folic acid)
170%
Calcium
6 mg
0%
Potas.
180 mg
4%
Riboflavin
6 mg
460%
Vit. B6
6 mg
350%
Vit. B12
14 mcg
580%
Top Medical Research Studies
9
We explored the effectiveness of monacolin K, the key ingredient in red yeast rice, in lowering cholesterol levels. An analysis of 12 randomized controlled trials with 769 participants revealed that monacolin K significantly reduced LDL and total cholesterol levels across various doses.
However, some participants experienced side effects, indicating mixed results regarding safety. While lower doses, such as 3mg/day, showed promise, ongoing monitoring for potential side effects is recommended for all users. Overall, monacolin K can be beneficial, but caution is essential.
However, some participants experienced side effects, indicating mixed results regarding safety. While lower doses, such as 3mg/day, showed promise, ongoing monitoring for potential side effects is recommended for all users. Overall, monacolin K can be beneficial, but caution is essential.
Read More
9
Red yeast rice reduces cholesterol
We examined the effects of red yeast rice (RYR) extract on cholesterol levels through a systematic review and meta-analysis of 14 double-blinded clinical trials. These studies showed that taking RYR significantly lowered total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels in participants. However, it did not affect high-density lipoprotein cholesterol or triglycerides. Importantly, RYR extract was deemed safe, with no serious side effects reported. Our findings suggest that while RYR may help manage cholesterol, more research is needed to confirm its long-term benefits and risks.
Read More
9
We examined how red yeast rice (RYR) could impact cholesterol levels, specifically low-density lipoprotein cholesterol (LDL-C). Our review highlighted that RYR can lower LDL-C levels by about 15-34% compared to a placebo, showing results similar to low-dose statins.
It’s noteworthy that RYR is safe and well-tolerated, offering another option for individuals with mild-to-moderate high cholesterol who cannot take statins or prefer not to use them. While it’s promising, it's essential to remember that RYR should complement lifestyle changes for the best results.
It’s noteworthy that RYR is safe and well-tolerated, offering another option for individuals with mild-to-moderate high cholesterol who cannot take statins or prefer not to use them. While it’s promising, it's essential to remember that RYR should complement lifestyle changes for the best results.
Read More
Most Useful Reviews
9
Promotes cholesterol health
2 people found this helpful
Fortified nutritional yeast is high in vitamin B12 and beneficial for athletes. It aids in lowering high cholesterol and supports muscle growth. This product helps supplement diets low in animal products, ensuring adequate nutrient intake.
Read More
9
Good for cholesterol
1 people found this helpful
I use nutritional yeast as a cheese substitute and enjoy its protein-rich content. It is fortified with B12, supports strong immunity, promotes lower high cholesterol levels, and is derived from sugar cane or beets.
Read More
7.5
Lowers cholesterol effectively
15 people found this helpful
Nutritional yeast has beneficial properties, including lowering high cholesterol. It contains antioxidants, boosts immunity, and supports healthy digestion. I find that it enhances the taste of dishes while also providing nutritional benefits. I preferred this brand for its delicate, cheesy flavour over others I tried.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
We evaluated the long-term effectiveness of a dietary supplement featuring red yeast rice and other natural compounds for children facing high cholesterol. In our study, 84 children and adolescents took the supplement daily for up to 16 months.
We noted significant reductions in harmful cholesterol levels, maintaining these benefits over time. However, there were no apparent changes in beneficial cholesterol or triglyceride levels.
While our findings suggest that this yeast-based product could be a safe option for managing cholesterol in kids, further research is needed to solidify its role and effectiveness.
We noted significant reductions in harmful cholesterol levels, maintaining these benefits over time. However, there were no apparent changes in beneficial cholesterol or triglyceride levels.
While our findings suggest that this yeast-based product could be a safe option for managing cholesterol in kids, further research is needed to solidify its role and effectiveness.
Read More
9
AI-guided supplements reduce cholesterol
In our exploration of how dietary supplements can tackle high cholesterol, we focused on whether AI-guided prescriptions work better than traditional ones. Conducting a randomized pilot study with 70 participants, we observed significant benefits from the AI approach.
Participants using AI guidance achieved a 25.3% reduction in LDL cholesterol, far surpassing the 15.2% reduction in the traditional group. Other results showed improvements in total cholesterol and triglycerides as well. These findings suggest that AI-driven supplement plans may enhance cholesterol management with minimal side effects.
Participants using AI guidance achieved a 25.3% reduction in LDL cholesterol, far surpassing the 15.2% reduction in the traditional group. Other results showed improvements in total cholesterol and triglycerides as well. These findings suggest that AI-driven supplement plans may enhance cholesterol management with minimal side effects.
Read More
9
Red yeast rice reduces cholesterol
We examined the effects of red yeast rice (RYR) extract on cholesterol levels through a systematic review and meta-analysis of 14 double-blinded clinical trials. These studies showed that taking RYR significantly lowered total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels in participants. However, it did not affect high-density lipoprotein cholesterol or triglycerides. Importantly, RYR extract was deemed safe, with no serious side effects reported. Our findings suggest that while RYR may help manage cholesterol, more research is needed to confirm its long-term benefits and risks.
Read More
9
We explored the effectiveness of monacolin K, the key ingredient in red yeast rice, in lowering cholesterol levels. An analysis of 12 randomized controlled trials with 769 participants revealed that monacolin K significantly reduced LDL and total cholesterol levels across various doses.
However, some participants experienced side effects, indicating mixed results regarding safety. While lower doses, such as 3mg/day, showed promise, ongoing monitoring for potential side effects is recommended for all users. Overall, monacolin K can be beneficial, but caution is essential.
However, some participants experienced side effects, indicating mixed results regarding safety. While lower doses, such as 3mg/day, showed promise, ongoing monitoring for potential side effects is recommended for all users. Overall, monacolin K can be beneficial, but caution is essential.
Read More
9
Monacolin K reduces LDL cholesterol
We explored the effects of a nutritional supplement containing red yeast rice on mild high cholesterol in a study involving 105 participants. The subjects were divided into three groups receiving different treatments alongside lifestyle changes for eight weeks.
Our findings showed a significant reduction in LDL cholesterol levels, with a 26.46% decrease for those taking a higher dose compared to a 16.77% decrease for the lower dose. We noted a slight reduction in triglycerides in the higher dose group but found no severe side effects during the study. This suggests that lower doses of monacolin K could still be effective in managing cholesterol levels.
Our findings showed a significant reduction in LDL cholesterol levels, with a 26.46% decrease for those taking a higher dose compared to a 16.77% decrease for the lower dose. We noted a slight reduction in triglycerides in the higher dose group but found no severe side effects during the study. This suggests that lower doses of monacolin K could still be effective in managing cholesterol levels.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Promotes cholesterol health
2 people found this helpful
Fortified nutritional yeast is high in vitamin B12 and beneficial for athletes. It aids in lowering high cholesterol and supports muscle growth. This product helps supplement diets low in animal products, ensuring adequate nutrient intake.
Read More
9
Good for cholesterol
1 people found this helpful
I use nutritional yeast as a cheese substitute and enjoy its protein-rich content. It is fortified with B12, supports strong immunity, promotes lower high cholesterol levels, and is derived from sugar cane or beets.
Read More
7.5
Lowers cholesterol effectively
15 people found this helpful
Nutritional yeast has beneficial properties, including lowering high cholesterol. It contains antioxidants, boosts immunity, and supports healthy digestion. I find that it enhances the taste of dishes while also providing nutritional benefits. I preferred this brand for its delicate, cheesy flavour over others I tried.
Read More
8
Combats high cholesterol
4 people found this helpful
Nutritional yeast is rich in vitamins and antioxidants, helping lower high cholesterol levels and improve skin condition. I consume it during winter to boost immunity, adding it to nut milk or juices, although its taste may not be very pleasant.
Read More
9
Improved cholesterol levels
1 people found this helpful
After using this product, I noticed positive changes in my health. The brand's quality is high, providing options for reducing high cholesterol while being easy to take. The environmentally friendly packaging also aligns with my sustainable consumption goals.
Read More
Frequently Asked Questions
9
Improved cholesterol levels
1 people found this helpful
After using this product, I noticed positive changes in my health. The brand's quality is high, providing options for reducing high cholesterol while being easy to take. The environmentally friendly packaging also aligns with my sustainable consumption goals.
7.5
Diabetes benefits
It is nutritious, provides energy, and is beneficial for diabetes, high blood pressure, and weight loss. From my experience, it has positively impacted my management of high cholesterol as well.
9
Promotes cholesterol health
2 people found this helpful
Fortified nutritional yeast is high in vitamin B12 and beneficial for athletes. It aids in lowering high cholesterol and supports muscle growth. This product helps supplement diets low in animal products, ensuring adequate nutrient intake.
8
Combats high cholesterol
4 people found this helpful
Nutritional yeast is rich in vitamins and antioxidants, helping lower high cholesterol levels and improve skin condition. I consume it during winter to boost immunity, adding it to nut milk or juices, although its taste may not be very pleasant.
9
Good for cholesterol
1 people found this helpful
I use nutritional yeast as a cheese substitute and enjoy its protein-rich content. It is fortified with B12, supports strong immunity, promotes lower high cholesterol levels, and is derived from sugar cane or beets.
7.5
Cholesterol-friendly option
9 people found this helpful
I diversified my diet by including nutritional yeast, which helps lower high cholesterol and offers protein and B vitamins. This sodium-free food suits nearly any diet and is beneficial for preventing vitamin B12 deficiency in vegetarians and vegans. I appreciate the feedback from others; stay healthy!
7.5
Cholesterol-lowering properties
1 people found this helpful
I liked the nutritional yeast for its health benefits. It contains beta-glucan, which supports immunity, lowers high cholesterol, and contains antioxidants and minerals. It’s a great seasoning for those who follow a low-sodium diet and adds a unique flavour to dishes.
9
We examined how red yeast rice (RYR) could impact cholesterol levels, specifically low-density lipoprotein cholesterol (LDL-C). Our review highlighted that RYR can lower LDL-C levels by about 15-34% compared to a placebo, showing results similar to low-dose statins.
It’s noteworthy that RYR is safe and well-tolerated, offering another option for individuals with mild-to-moderate high cholesterol who cannot take statins or prefer not to use them. While it’s promising, it's essential to remember that RYR should complement lifestyle changes for the best results.
It’s noteworthy that RYR is safe and well-tolerated, offering another option for individuals with mild-to-moderate high cholesterol who cannot take statins or prefer not to use them. While it’s promising, it's essential to remember that RYR should complement lifestyle changes for the best results.
7
RYR poses health risks; PCO is protective
We explored the effects of red yeast rice (RYR) and policosanol (PCO) on high cholesterol levels in zebrafish over a 12-week period. The results were telling: while both substances helped reduce cholesterol and triglycerides, PCO showed significant benefits, even boosting good cholesterol levels. Unfortunately, RYR was linked to serious liver and kidney damage, raising concerns about its safety. Thus, while yeast treatments like RYR provided some cholesterol-lowering effects, they come with worrying health risks compared to the safer profile of PCO.
9
Red yeast rice reduces cholesterol
We examined the effects of red yeast rice (RYR) extract on cholesterol levels through a systematic review and meta-analysis of 14 double-blinded clinical trials. These studies showed that taking RYR significantly lowered total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels in participants. However, it did not affect high-density lipoprotein cholesterol or triglycerides. Importantly, RYR extract was deemed safe, with no serious side effects reported. Our findings suggest that while RYR may help manage cholesterol, more research is needed to confirm its long-term benefits and risks.
8
Policosanol brand efficacy varies significantly
We explored how different policosanol brands influence high cholesterol levels in zebrafish over six weeks. Each brand, including Raydel and others from around the world, was added to the fish diet while they were also fed a high-cholesterol diet.
Our findings showed that most brands effectively lowered total cholesterol and triglycerides, with Raydel achieving the best results in raising good cholesterol levels. Interestingly, some brands could even worsen liver damage linked to high cholesterol.
This study highlights significant differences in the effectiveness of policosanol brands, underlining the importance of product formulation in cholesterol management.
Our findings showed that most brands effectively lowered total cholesterol and triglycerides, with Raydel achieving the best results in raising good cholesterol levels. Interestingly, some brands could even worsen liver damage linked to high cholesterol.
This study highlights significant differences in the effectiveness of policosanol brands, underlining the importance of product formulation in cholesterol management.
8
We investigated the effectiveness of buffalo yoghurt made from specific probiotic strains in reducing cholesterol levels. This study involved producing the yoghurt with three different probiotics, analyzing its antioxidant and ACE-inhibitory properties over a 28-day storage period.
While we observed a notable cholesterol assimilation effect, especially with Lactiplantibacillus plantarum, the beneficial impact on overall cholesterol reduction wasn’t significant. The probiotics remained viable throughout the study, suggesting potential for future research but did not conclusively lower cholesterol levels in this formulation.
While we observed a notable cholesterol assimilation effect, especially with Lactiplantibacillus plantarum, the beneficial impact on overall cholesterol reduction wasn’t significant. The probiotics remained viable throughout the study, suggesting potential for future research but did not conclusively lower cholesterol levels in this formulation.
References
- Cho KH, Bahuguna A, Kim JE, Lee SH, Lee Y, et al. A Comparative Effect of 12-Week Dietary Intervention of Policosanol (Raydel) and Red Yeast Rice (RYR, Kobayashi) in Managing Dyslipidemia and Organ Damage in Hyperlipidemic Zebrafish. Pharmaceuticals (Basel). 2025;18. 10.3390/ph18020200
- Akbal S, Uğur Geçer E, Ertürkmen P. Probiotic Viability and Bioactive Properties of Buffalo Yoghurt Produced Using High Cholesterol-Assimilating Probiotic Strains. Vet Med Sci. 2025;11:e70233. 10.1002/vms3.70233
- Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. 10.3390/biom14121608
- Pokushalov E, Ponomarenko A, Smith J, Johnson M, Garcia C, et al. Efficacy of AI-Guided (GenAIS) Dietary Supplement Prescriptions versus Traditional Methods for Lowering LDL Cholesterol: A Randomized Parallel-Group Pilot Study. Nutrients. 2024;16. 10.3390/nu16132023
- Cho KH, Bahuguna A, Kim JE, Lee SH. Efficacy Assessment of Five Policosanol Brands and Damage to Vital Organs in Hyperlipidemic Zebrafish by Six-Week Supplementation: Highlighting the Toxicity of Red Yeast Rice and Safety of Cuban Policosanol (Raydel). Pharmaceuticals (Basel). 2024;17. 10.3390/ph17060714
- Trogkanis E, Karalexi MA, Sergentanis TN, Kornarou E, Vassilakou T. Safety and Efficacy of the Consumption of the Nutraceutical "Red Yeast Rice Extract" for the Reduction of Hypercholesterolemia in Humans: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. 10.3390/nu16101453
- Hsueh TP, Lin WL, Hu WL, Hung YC. Red Yeast Rice and Statin Therapy in Patients with Hypercholesterolemia and the Comorbidities: A Retrospective Cohort Study on Lipid-Lowering Effects and Cardiovascular Outcomes. Am J Chin Med. 2024;52:417. 10.1142/S0192415X24500174
- Liasi E, Kantilafti M, Hadjimbei E, Chrysostomou S. Monacolin K supplementation in patients with hypercholesterolemia: A systematic review of clinical trials. Semergen. 2024;50:102156. 10.1016/j.semerg.2023.102156
- Liu X, Zeng X, Mahe J, Guo K, He P, et al. The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2023;15. 10.3390/nu15194239
- Angelopoulos N, Paparodis RD, Androulakis I, Boniakos A, Argyrakopoulou G, et al. Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial. Nutrients. 2023;15. 10.3390/nu15122682
- Cicero AFG, Fogacci F, Stoian AP, Toth PP. Red Yeast Rice for the Improvement of Lipid Profiles in Mild-to-Moderate Hypercholesterolemia: A Narrative Review. Nutrients. 2023;15. 10.3390/nu15102288
- Ardissino D, Colletti A, Pellizzato M, Pagliari G, Di Pierro F, et al. Short-Term Effect of Nutraceutical Fruit Juices on Lipid Metabolism in Patients with Acquired Hypercholesterolemia. Int J Mol Sci. 2023;24. 10.3390/ijms24087358
- Zhou H, Liu W, Lv Y, Liu K, Wang Y, et al. Supplementation with Natto and Red Yeast Rice Alters Gene Expressions in Cholesterol Metabolism Pathways in ApoE Mice with Concurrent Changes in Gut Microbiota. Nutrients. 2023;15. 10.3390/nu15040973
- Lata P, Kumari R, Sharma KB, Rangra S. In vitro evaluation of probiotic potential and enzymatic profiling of Pichia kudriavzevii Y33 isolated from traditional home-made mango pickle. J Genet Eng Biotechnol. 2022;20:132. 10.1186/s43141-022-00416-2
- Osadnik T, Goławski M, Lewandowski P, Morze J, Osadnik K, et al. A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults. Pharmacol Res. 2022;183:106402. 10.1016/j.phrs.2022.106402
- Lee H, Jang SY, Jung Y, Kwon O, Hwang GS. Lipidomic profiling analysis of human plasma from subjects with hypercholesterolemia to evaluate the intake of yellow yeast rice fermented by DSMK01. Food Funct. 2022;13:7629. 10.1039/d1fo04010c
